KMID : 1161420200230090928
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Journal of Medicinal Food 2020 Volume.23 No. 9 p.928 ~ p.937
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Geraniin Protects PC12 Cells Against A¥â25?35-Mediated Neuronal Damage: Involvement of NF-¥êB and MAPK Signaling Pathways
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Youn Kum-Ju
Jun Mi-Ra
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Abstract
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¥â-amyloid peptide (A¥â) has been considered a critical factor that is associated with the development of oxidative stress and neuroinflammation in the pathogenesis of Alzheimer's disease. This study was performed to evaluate the effect of geraniin on A¥â25?35-caused oxidative damage and neuroinflammatory response, and its underlying mechanism. Geraniin protected pheochromocytoma12 (PC12) cells from A¥â25?35-mediated cell death by reducing oxidative stress and restoring cell cycle dysregulation. Moreover, geraniin markedly attenuated A¥â-triggered DNA injury that was partially associated with decreases in caspase-3 activity. Moreover, the compound significantly downregulated the release of neuroinflammatory factors. Upregulation of nuclear factor-¥êB activity was suppressed by geraniin, which was due to suppression of JNK, ERK1/2, and the p38 mitogen-activated protein kinase (MAPK) pathway. This was the first study to support further understanding of geraniin as a promising agent against neurotoxicity in the reduction of oxidative stress and neuroinflammation.
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KEYWORD
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Alzheimer's disease, amyloid-¥â peptide, geraniin, neuroinflammation, oxidative stress
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